Passage of lanthanum through the intercellular spaces of the sebaceous gland

Lanthanum introduced intradermally into cattle, sheep, goats, ponies and rats penetrated into the sebum through the intercellular spaces of the sebaceous gland. It is concluded that the sebaceous gland is permeable to the passage of small molecules outwards and probably in some circumstances inwards. Since the constituents of sebum are not all produced by necrosis it is likely that the sebaceous gland is not a simple holocrine gland.