喹赛多的合成工艺研究

以苯并呋咱-N-氧化物和丙酮醛缩二甲醇为起始原料,N,N-二甲基甲酰胺为溶剂,吡咯烷为催化剂,经过Beirut反应得到喹噁啉-1,4-二氧-2-甲醛缩二甲醇,喹噁啉-1,4-二氧-2-甲醛缩二甲醇在以甲醇为溶剂、浓盐酸为催化剂的条件下与氰乙酰肼反应生成喹赛多.终产物喹赛多经核磁共振氢谱、核磁共振碳谱、质谱、红外光谱进行确证.总收率为55.8％.

The Synthesis Technologic Study of Cyadox

2-formylquinoxaline-1, 4-dioxide dimethylacetal was obtained by benzofuroxan-N-oxide and pyruvaldehyde dimethylacetal which were dissolved in N,N-dimethyl formamide and pyrrolidine was used as catalyzer. 2-formylquinoxaline-1, 4-dioxide dimethylacetal was dissolved in methanol and concentrated hydrochloric acid, then reacted with cyanoacetylhydrazine to obtain cyadox. Cyadox was identified by ¹H-NMR, ^{13C-NMR, MS, and IR. The total yield was 55.8%.}