环氧合酶-2和微血管密度与胃癌淋巴结转移及临床分期的关系

目的观察胃癌组织中环氧合酶（COX-2）的表达及微血管密度与患者淋巴结转移之间的关系。方法检测COX-2在胃癌细胞中的表达、计算肿瘤组织中微血管密度值，观察它们与患者临床分期、淋巴结转移的关系。结果COX-2的表达主要分布在胞浆，Ⅰ期胃癌细胞均未表达COX-2，随淋巴结转移站别的增高，阳性级别增加。随淋巴结转移站别的增高，胃癌组织中微血管密度明显增加，组间比较差异有统计学意义（P〈0．01）；随胃癌TNM分期的增高，COX-2表达增多，微血管密度明显增加，组间比较差异有统计学意义（P〈0．01或0．05）。结论胃癌组织中COX．2的表达及微血管密度与患者淋巴结转移之间有密切的关系。随淋巴结转移站别的增高，COX-2表达增多，微血管密度明显增加。

Associations of cyclooxygenase-2 and micro-vessel density with lymph node metastasis and clinical staging in gastric cancer

Objective To observe the associations of cyclcoxygenase-2 （COX-2） and micro-vessel derksity （MVD） with lymph node metastasis and clinical staging in gastric cancer. Methods COX-2 expression in gastric carcinoma cells was detected and MVD value in tumor tissue was calculated. The association of COX-2 and MVD with lymph node metastasis and TNM staging in gastric cancer was analyzed. Results COX-2 mainly expressed in cytoplasm and could not be detected in gastric cancer cells of TNM stage Ⅰ. The positive expression strength of COX-2 was increasing as the lymph node metastasis increased. The MVD value in cancer tissue obviously increased as the lymph node metastasis increased, with a significant difference among the groups （P 〈 0.01）. Both COX-2 expression and MVD value increased as the TNM stage progressed, with a significant difference among the groups （P〈0.01 or 0.05）. Conclusion The COX-2 expression and the MVD value are associated with lymph node metastasis and TNM stage in gastric carcinoma.