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| IL-10在结核分枝杆菌感染和免疫中作用的研究进展 | |
| 引用本文： | 竺婷婷,卜棚,刘晗,彭永崇,陈颖钰,郭爱珍.IL-10在结核分枝杆菌感染和免疫中作用的研究进展[J].中国畜牧兽医,2017,44(5):1462-1467. |
| 作者姓名： | 竺婷婷 卜棚 刘晗 彭永崇 陈颖钰 郭爱珍 |
| 作者单位： | 1. 华中农业大学农业微生物学国家重点实验室, 武汉 430070; 2. 华中农业大学动物医学院, 武汉 430070 |
| 基金项目： | 国家自然科学基金面上项目（31472219）；现代农业（肉牛牦牛）产业技术体系专项基金（CARS-38） |
| 摘 要： | 白细胞介素10（interleukin 10，IL-10）是一种多功能、多细胞源性的细胞因子，因其具有强抗炎和免疫抑制活性而成为研究热点。在结核病的发生发展中，IL-10的免疫抑制作用受到了研究者的关注，其既能抑制天然免疫，也能影响获得性免疫。研究者普遍认为IL-10与结核分枝杆菌的免疫逃避及潜伏性感染有关。鉴于其在结核分枝杆菌感染中独特的作用，作者对近几年IL-10在结核分枝杆菌免疫逃避、潜伏感染、临床辅助治疗及自身表达调控等方面的研究进展进行了综述。 |
| 关 键 词： | IL-10 结核分枝杆菌 免疫调控 感染 |
| 收稿时间： | 2016-10-31 |
Research Progress on Role of IL-10 in Immunodulation during Mycobacterium tuberculosis Infection |
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| ZHU Ting-ting,PU Peng,LIU Han,PENG Yong-chong,CHEN Ying-yu,GUO Ai-zhen.Research Progress on Role of IL-10 in Immunodulation during Mycobacterium tuberculosis Infection[J].China Animal Husbandry & Veterinary Medicine,2017,44(5):1462-1467. | |
| Authors: | ZHU Ting-ting PU Peng LIU Han PENG Yong-chong CHEN Ying-yu GUO Ai-zhen |
| Institution: | 1. State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; 2. College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China |
| Abstract: | Interleukin 10 (IL-10) is a versatile and multi-cell derived cytokine, which has attracted the great attention of researchers because of its strong anti-inflammation and immunosuppression activities. It can not only inhibit the innate but also adaptive immunity. Generally, it is believed that IL-10 is closely related to immune evasion and latent infection by Mycobacterium tuberculosis (MTB). In view of its unique role in MTB infection, progress of role of IL-10 on immune evasion, latent infection, clinical chemotherapies and self-regulation of its expression during MTB infection were reviewed. |
| Keywords: | IL-10 Mycobacterium tuberculosis immunomodulation infection |
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