ESR、OPN和RBP4基因多态性对大白猪繁殖性状的影响

为了探讨雌激素受体（estrogen receptor，ESR）、骨桥蛋白（osteopontin，OPN）和视黄醇结合蛋白4（retinol binding proteins 4，RBP4）的多态性对大白猪繁殖性状的影响，本研究采用PCR-RFLP技术检测试验猪群ESR、OPN和RBP4基因的多态性，并分析其对大白猪总产仔数、产活仔数、健仔数、窝重、初生重、死胎、木乃伊、弱仔数和畸形数等性状的影响。结果显示，在大白经产母猪中，ESR和OPN基因的优势基因为A等位基因，RBP4基因的优势基因为B等位基因；ESR基因AB与BB基因型在总产仔数、产活仔数性状上均高于AA基因型；OPN基因在总产仔数性状上AA基因型最高，在产活仔数、健仔数、窝重性状上均为BB > AA > AB；RBP4基因在总产仔数、产活仔数、健仔数、窝重性状上均为AA > BB > AB；合并基因型分析发现ESR-RBP4最优的分子标记组合为ABAA；OPN-RBP4最优的分子标记组合为BBAA。因此，ESR、OPN和RBP4基因多态性与大白猪繁殖性状相关。

Influence of ESR,OPN and RBP4 Genes Polymorphisms on Reproductive Traits of Yorkshire Sows

To study the influence of estrogen receptor (ESR), osteopontin (OPN) and retinol binding proteins 4 (RBP4) genotypes on reproductive performance of Yorkshire sows, PCR-RLFP technique was used for genotyping, and the effects of genotypes on reproductive traits were analyzed. The results showed that A allele of ESR and OPN genes were predominant allele, and B allele of RBP4 gene was predominant allele. TNB,NBA of ESR gene AB and BB genotypes were higher than AA genotype;TNB of OPN gene AA genotype was the highest, but the NBA, NHB and WB for OPN gene genotypes were BB > AA > AB;The TNB,NBA,NHB and WB for RBP4 gene genotypes were AA > BB > AB. Then combing genotype analysis showed that ABAA of ESR-RBP4 and BBAA of OPN-RBP4 were the most prolific alleles, respectively. The present data revealed that ESR, OPN and RBP4 genes polymorphisms were associated with reproductive performance of Yorkshire sows.