| 磺胺二甲嘧啶生理药动学模型种间类推的应用 |
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| 引用本文： | 罗显阳,远立国.磺胺二甲嘧啶生理药动学模型种间类推的应用[J].中国畜牧兽医,2010,37(3):194-197. |
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| 作者姓名： | 罗显阳 远立国 |
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| 作者单位： | （华南农业大学兽医学院， 广州 510642） |
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| 摘 要： | 本研究应用磺胺二甲嘧啶在猪的生理药动学模型来预测其在绵羊体内的动力学过程。利用文献中已经建立的猪的生理模型,采用动物种间类推原理,将模型外推至绵羊,模拟磺胺二甲嘧啶在绵羊体内的血药和组织浓度,并估算可食性组织残留休药期。结果模拟休药期和文献休药期基本趋于一致,表明生理药动学模型种间类推是可行的。
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| 关 键 词： | 磺胺二甲嘧啶 生理药动学模型 绵羊 |
The Interspecies Extrapolation of Sulfamethazine Physiologically Based Pharmacokinetic Model |
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| LUO Xian-yang,YUAN Li-guo.The Interspecies Extrapolation of Sulfamethazine Physiologically Based Pharmacokinetic Model[J].China Animal Husbandry & Veterinary Medicine,2010,37(3):194-197. |
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| Authors: | LUO Xian-yang YUAN Li-guo |
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| Institution: | (College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642，China) |
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| Abstract: | The objective of this paper was to predict kinetic process of Sulfamethazine in sheep on the basis of the physiologically based pharmacokinetic model of Sulfamethazine in pig.The PBPK model in pig was extrapolated to sheep based on the interspecies scaling theory,to simulate the plasma and tissues concentration of Sulfamethazine and estimate residue withdrawal times in edible tissues in sheep.The results showed that the simulated withdrawal times was according to the reported withdrawal times.The interspeci... |
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| Keywords: | Sulfamethazine physiologically based pharmacokinetic model sheep |
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