| 转基因植物疫苗研究进展 |
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| 引用本文： | 傅玲琳,帅江冰,许梓荣. 转基因植物疫苗研究进展[J]. 中国兽药杂志, 2005, 39(5): 22-26 |
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| 作者姓名： | 傅玲琳 帅江冰 许梓荣 |
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| 作者单位： | 1. 浙江大学教育部动物分子营养学重点实验室,浙江,杭州,310029
2. 浙江大学动物预防医学研究所,浙江,杭州,310029 |
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| 摘 要： | 众多研究表明,病毒的抗原决定簇及细菌毒素亚单位均能在转基因植物中成功表达,并保持良好的免疫原性.与现有的疫苗生产体系相比,植物生产疫苗具有安全、经济、稳定、高效等优势.本文概述了利用不同受体植物生产疫苗的研究现状、免疫原性评价及免疫原基因的优化表达策略.
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| 关 键 词： | 转基因植物 疫苗 优化表达 免疫原性 |
| 文章编号： | 1002-1280(2005)05-0022-05 |
| 修稿时间： | 2004-10-26 |
Research progress of transgenic plant-derived vaccines |
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| FU Ling-lin,SHUAI Jiang-bing,Jha Rajeev Kumar,XU Zi-rong. Research progress of transgenic plant-derived vaccines[J]. Chinese Journal of Veterinary Drug, 2005, 39(5): 22-26 |
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| Authors: | FU Ling-lin SHUAI Jiang-bing Jha Rajeev Kumar XU Zi-rong |
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| Abstract: | Numerous studies have shown that viral epitopes and subunits of bacterial toxins can be expressed and correctly processed in transgenic plants. The recombinant proteins induce immune responses and have several (benefits) over current vaccine technologies, including increased safety, economy, stability and efficacy. Examples of different types of expression systems producing a variety of vaccine candidates are illustrated, as well as their immunogenicity evaluation. This review also includes strategies on optimal expression of immunogenic genes in transgenic plants vaccine and its application prospects. |
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| Keywords: | transgenic plants vaccine optimal expression immunogenicity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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