Effect of cilobradine in cats with a first episode of congestive heart failure due to primary cardiomyopathy |
| |
| Institution: | 1. Corresponding Address Kardiovet GmbH, Eystrasse 74, Kirchberg, Switzerland;2. Department for Companion Animals and Horses, University of Veterinary Medicine, Veterinärplatz, Vienna, Austria;3. Centre Hospitalier Vétérinaire des Cordeliers, 35 Avenue Du Maréchal Joffre, 77100 Meaux, France;4. Tierärztliche Gemeinschaftspraxis, An Den Wurthen 26, 17489 Greifswald, Germany;5. Medisch Centrum voor Dieren, Isolatorweg 45, 1014 AS Amsterdam, the Netherlands;6. Small Animal Teaching Hospital, Department of Small Animal Clinical Science, Institute of Veterinary Science, University of Liverpool, Leahurst Campus, Chester High Road, Neston, Cheshire CH64 7TE, UK;7. Tierklinik Bockenheim, Juliusstrasse 12, 60487 Frankfurt, Germany;8. Ross University School of Veterinary Medicine, Basseterre, St. Kitts West Indies, St. Kitts and Nevis;9. Kleintierspezialisten Dres. Schmerbach & Höpfner, Wittestr. 30, 13509 Berlin, Germany;10. Tiergesundheitszentrum Obere Hard, Überweisungspraxis für Innere Medizin und Kardiologie, Oberer Hardweg 16, 75181 Pforzheim, Germany;11. Barton Veterinary Hospital and Surgery, CVS (UK) Ltd, 34 New Dover Road, Canterbury, Kent CT1 3BH, UK;12. North Downs Specialist Referrals, The Friesian Building 3 & 4, The Brewerstreet Dairy Business Park, Brewer Street, Bletchingley, Surrey RH1 4QP, UK;13. Clinique Vétérinaire Aquivet, 19 Avenue de La Forêt, Parc d''activités Mermoz, 33320 Eysines, France;14. Clinique Vétérinaire Armonia, Rue Serge Mauroit, 38090 Villefontaine, France;15. Aalborg Dyrehospital, Fredrikstadvej 10, 9200 Aalborg SV, Denmark;p. Kleintierzentrum Walluf, Am Klingenweg 21, 65396 Walluf, Germany;q. Tierärztliche Klinik Oberhaching, Bajuwarenring 10, 82041 Oberhaching, Germany;r. Oncovet Clinique Vétérinaire de Référés, Avenue Paul Langevin, 59650 Villeneuve d''Ascq, France;s. Ivy Court, Willington Rd, Etwall, Derbyshire DE65 6JG, UK;t. Anderson Moores Veterinary Specialists, The Granary, Bunstead Barns, Poles Lane, Hursley, Winchester, Hampshire SO21 2LL, UK;u. Clinic of Small Animal Medicine, Ludwig-Maximilians University, Veterinärstrasse 13, 80539 Munich, Germany;v. Clinique Vétérinaire Foch, 38 Avenue du Maréchal Foch, 34500 Beziers, France;w. Boehringer Ingelheim Vetmedica GmbH Binger Strasse 173, 55216 Ingelheim Am Rhein, Germany;1. Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 204 Duck Pond Drive, Blacksburg, VA 24061-0442, USA;2. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA;3. Department of Veterinary Sciences, University of Parma, Strada del Taglio 10, 43126 PR, Italy;4. Department of Clinical Science, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Science, Box 7054, Uppsala, Sweden;5. CVCA Cardiac Care for Pets, 1209 Cromwell Bridge Road, Towson, MD 21286, USA;6. CVCA Cardiac Care for Pets, 165 Fort Evans Road NE, Leesburg, VA 20176, USA;1. Clinica Veterinaria Malpensa, AniCura, Viale Marconi, 27, 21017, Samarate, VA, Italy;2. Ospedale Veterinario I Portoni Rossi, AniCura, Via Roma 57, 40069, Zola Predosa, BO, Italy;3. Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra, 50, 40064, Ozzano Dell''Emilia, BO, Italy;4. Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, 930 Campus Road, 14853, Ithaca, NY, USA;2. Department of Veterinary Sciences, University of Parma, Strada del Taglio, 10, 43126, Parma, Italy |
| |
| Abstract: | IntroductionHeart rate (HR) is often elevated in cats with cardiomyopathies (CMPs). Pharmacologic modulation of HR may reduce cardiac morbidity and mortality.ObjectivesTo investigate the effects of cilobradine vs. placebo, regarding time to cardiac mortality or morbidity in cats with first episode of congestive heart failure (CHF) due to primary CMP.AnimalsThree hundred and sixty-seven client-owned cats with primary CMP that had presented with a first episode of CHF at 50 centers in Europe. Per-protocol population comprised 193 cats (n = 89 cilobradine, n = 104 placebo). An interim analysis for futility was planned.MethodsProspective, randomized, placebo-controlled, double-blinded, multicenter clinical trial. Primary outcome variable was the time to a composite of cardiac mortality or cardiac morbidity.ResultsMedian time to primary outcome was 84 days (95% confidence interval CI]: 63–219 days) in the cilobradine group (CG) and 203 days in the placebo group (95% CI: 145–377 days) with observed hazard ratio of 1.44, indicating a higher hazard for the CG (P = 0.057). Mean HR was 28 beats per minute (bpm) lower at Day 7 (P < 0.0001) and remained 29 bpm lower at Day 360 (P = 0.026) in the CG than that in the placebo group. Although the number of adverse events did not differ, there were more serious adverse events in the CG.ConclusionsHeart rate reduction by cilobradine in cats with a first episode of CHF due to primary CMP did not reduce cardiac mortality and morbidity. |
| |
| Keywords: | Heart disease Cardiology Feline Heart rate Clinical trial |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
