Association of diet with clinical outcomes in dogs with dilated cardiomyopathy and congestive heart failure |
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| Institution: | 1. School of Veterinary Medicine, University of California, Davis,1 Garrod Drive, Davis, CA, 95616, USA;2. College of Veterinary Medicine, North Carolina State University, 1060 William Moore Dr., Raleigh, NC, 27607, USA;3. MedVet Chicago, 3305 N, California Ave., Chicago, IL, 60618, USA;4. MedVet Columbus, 300 E, Wilson Bridge Rd., Worthington, OH, 43085, USA;5. The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, United Kingdom;6. College of Veterinary Medicine, University of Florida, 2015 SW 16th Ave., Gainesville, FL, 32608, USA;2. Department of Veterinary Sciences, University of Parma, Strada del Taglio, 10, 43126, Parma, Italy;1. Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 204 Duck Pond Drive, Blacksburg, VA 24061-0442, USA;2. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA;3. Department of Veterinary Sciences, University of Parma, Strada del Taglio 10, 43126 PR, Italy;4. Department of Clinical Science, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Science, Box 7054, Uppsala, Sweden;5. CVCA Cardiac Care for Pets, 1209 Cromwell Bridge Road, Towson, MD 21286, USA;6. CVCA Cardiac Care for Pets, 165 Fort Evans Road NE, Leesburg, VA 20176, USA;1. Corresponding Address Kardiovet GmbH, Eystrasse 74, Kirchberg, Switzerland;2. Department for Companion Animals and Horses, University of Veterinary Medicine, Veterinärplatz, Vienna, Austria;3. Centre Hospitalier Vétérinaire des Cordeliers, 35 Avenue Du Maréchal Joffre, 77100 Meaux, France;4. Tierärztliche Gemeinschaftspraxis, An Den Wurthen 26, 17489 Greifswald, Germany;5. Medisch Centrum voor Dieren, Isolatorweg 45, 1014 AS Amsterdam, the Netherlands;6. Small Animal Teaching Hospital, Department of Small Animal Clinical Science, Institute of Veterinary Science, University of Liverpool, Leahurst Campus, Chester High Road, Neston, Cheshire CH64 7TE, UK;7. Tierklinik Bockenheim, Juliusstrasse 12, 60487 Frankfurt, Germany;8. Ross University School of Veterinary Medicine, Basseterre, St. Kitts West Indies, St. Kitts and Nevis;9. Kleintierspezialisten Dres. Schmerbach & Höpfner, Wittestr. 30, 13509 Berlin, Germany;10. Tiergesundheitszentrum Obere Hard, Überweisungspraxis für Innere Medizin und Kardiologie, Oberer Hardweg 16, 75181 Pforzheim, Germany;11. Barton Veterinary Hospital and Surgery, CVS (UK) Ltd, 34 New Dover Road, Canterbury, Kent CT1 3BH, UK;12. North Downs Specialist Referrals, The Friesian Building 3 & 4, The Brewerstreet Dairy Business Park, Brewer Street, Bletchingley, Surrey RH1 4QP, UK;13. Clinique Vétérinaire Aquivet, 19 Avenue de La Forêt, Parc d''activités Mermoz, 33320 Eysines, France;14. Clinique Vétérinaire Armonia, Rue Serge Mauroit, 38090 Villefontaine, France;15. Aalborg Dyrehospital, Fredrikstadvej 10, 9200 Aalborg SV, Denmark;p. Kleintierzentrum Walluf, Am Klingenweg 21, 65396 Walluf, Germany;q. Tierärztliche Klinik Oberhaching, Bajuwarenring 10, 82041 Oberhaching, Germany;r. Oncovet Clinique Vétérinaire de Référés, Avenue Paul Langevin, 59650 Villeneuve d''Ascq, France;s. Ivy Court, Willington Rd, Etwall, Derbyshire DE65 6JG, UK;t. Anderson Moores Veterinary Specialists, The Granary, Bunstead Barns, Poles Lane, Hursley, Winchester, Hampshire SO21 2LL, UK;u. Clinic of Small Animal Medicine, Ludwig-Maximilians University, Veterinärstrasse 13, 80539 Munich, Germany;v. Clinique Vétérinaire Foch, 38 Avenue du Maréchal Foch, 34500 Beziers, France;w. Boehringer Ingelheim Vetmedica GmbH Binger Strasse 173, 55216 Ingelheim Am Rhein, Germany;1. Bluepearl Veterinary Partners, 4126 Packard Road, Ann Arbor, Michigan, 48108, USA;2. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 736 Wilson Road, East Lansing, Michigan, 48824, USA |
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| Abstract: | IntroductionDilated cardiomyopathy (DCM) in dogs has been associated with feeding of grain-free (GF), legume-rich diets. Some dogs with presumed diet-associated DCM have shown improved myocardial function and clinical outcomes following a change in diet and standard medical therapy.HypothesisPrior GF (pGF) diet influences reverse cardiac remodeling and clinical outcomes in dogs with DCM and congestive heart failure (CHF).Animals and methodsA retrospective study was performed with 67 dogs with DCM and CHF for which diet history was known. Dogs were grouped by diet into pGF and grain-inclusive (GI) groups. Dogs in the pGF group were included if diet change was a component of therapy. Survival was analyzed using Kaplan–Meier curves and the Cox proportional-hazards model.ResultsThe median survival time was 344 days for pGF dogs vs. 253 days for GI dogs (P = 0.074). Statistically significant differences in median survival were identified when the analysis was limited to dogs surviving longer than one week (P = 0.033). Prior GF dogs had a significantly worse outcome the longer a GF diet was fed prior to diagnosis (P = 0.004) or if they were diagnosed at a younger age (P = 0.017). Prior GF dogs showed significantly greater improvement in normalized left ventricular internal diastolic diameter (P = 0.038) and E-point septal separation (P = 0.031) measurements and significant decreases in their furosemide (P = 0.009) and pimobendan (P < 0.005) dosages over time compared to GI dogs.ConclusionsPrior GF dogs that survived at least one week after diagnosis of DCM, treatment of CHF, and diet change had better clinical outcomes and showed reverse ventricular remodeling compared to GI dogs. |
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| Keywords: | Canine Survival Grain-free Echocardiography Nutritional |
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