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Characterization of a novel coronavirus associated with severe acute respiratory syndrome |
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| Authors: | Rota Paul A Oberste M Steven Monroe Stephan S Nix W Allan Campagnoli Ray Icenogle Joseph P Peñaranda Silvia Bankamp Bettina Maher Kaija Chen Min-Hsin Tong Suxiong Tamin Azaibi Lowe Luis Frace Michael DeRisi Joseph L Chen Qi Wang David Erdman Dean D Peret Teresa C T Burns Cara Ksiazek Thomas G Rollin Pierre E Sanchez Anthony Liffick Stephanie Holloway Brian Limor Josef McCaustland Karen Olsen-Rasmussen Melissa Fouchier Ron Günther Stephan Osterhaus Albert D M E Drosten Christian Pallansch Mark A Anderson Larry J Bellini William J |
| Institution: | National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. prota@cdc.gov |
| Abstract: | In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses. |
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