Immune surveillance mechanisms of the skin against the stealth infection strategy of Pseudomonas aeruginosa—Review

The present review aims to provide insight into the complex interactions between the host and Pseudomonas aeruginosa—an opportunistic microbial agent causing skin infections. Heat, humidity and skin pH are among the factors beneficial for the development of this Gram-negative agent. To cause infection, Pseudomonas aeruginosa should first overcome the primary mechanisms of defense including the cell elements and humoral factors of the skin, as well as non-specific responses—phagocytosis, inflammation, acute phase response. All they are analysed with emphasis on the fact that their detailed understanding would help revealing their potential and allow for their efficient control.