鹿茸角发育与再生机理

对鹿茸角发育与再生调节机理的研究进展进行了综述,并对与鹿茸角发育与再生相关的一些生理问题进行了探讨。已确认的与鹿茸角再生关系密切的重要分子有甲状旁腺激素相关肽、视黄酸、胰岛素样生长因子等,这些物质广泛分布于芽基及快速生长的鹿茸角内,可调节软骨细胞、成骨细胞及破骨细胞的分化。由于鹿茸角再生过程与生殖周期密切相关,性激素可能对这些因子在鹿茸角内的表达起调节作用

The Mechanisms of Deer Antlers Development and Regeneration

There is a unique model of mammalian organ regeneration and wound repair. But the underlying mechanisms of regeneration remain poorly understood. This article reviews what is currently known about the local and systemic regulation of antler development and regeneration and some of the related unsolved questions of antler physiology is discussed. Molecules that have been identified as having potentially important local roles in antlers include parathyroid hormone-related peptide, retinoic acid (RA) and insulin-like growth factors (IGFs). All of them are present in the blastema and in the rapidly growing antler where they regulate the differentiation of chondrocytes, osteoblasts and osteoclasts. The trigger that regulates the expression of these local signals is likely to be changing levels of sex steroids because the process of antler regeneration is linked to the reproductive cycle.