蟛蜞菊对小白鼠的急性毒性试验

为全面评定蟛蜞菊的安全性，在进行蟛蜞菊对肉兔的慢性毒性试验的基础上，本试验采用灌胃法，通过对小白鼠的脏器系数比较及组织病理学观察，测定了蟛蜞菊对小白鼠的急性毒性作用。试验结果如下：①试验结束后，对照组和试验组小白鼠都无死亡；②宰杀的试验组小白鼠的各脏器无明显肉眼可见剖检病变；③试验组小白鼠的各脏器系数与对照组的差异不显著（P>0.05）；④试验组小白鼠肝脏的组织形态发生轻微变化，其他脏器正常。研究结果表明，蟛蜞菊可安全用于动物饲料。

Acute Toxicity Test of Wedelia Chinensis to Mice

In order to fully evaluate the safety of the Wedelia chinensis, based on the chronic toxicity test of Wedelia chinensis to rabbits, we conducted the acute toxicity test of Wedelia chinensis to mice administered by oral. In the test, we observed the histopathology of the mice and compared their viscera coefficients. The results showed that: ①In the course of the test, mice of the control or test group didn’t die; ②There was no pathological change been found in viscera, after mice of the test group were killed; ③Viscera coefficients of mice were no significant difference (P>0.05) between the control and test group; ④Liver tissue of mice in test group changed slightly, while other viscera had no change. It indicated that: Wedelia chinensis can be safely used as animals’ forage.