| 乳酸恩诺沙星对小鼠的急性毒性试验 |
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| 引用本文： | 唐一鸣,姜中其,陈俭. 乳酸恩诺沙星对小鼠的急性毒性试验[J]. 中国兽药杂志, 2010, 44(4): 29-30,60 |
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| 作者姓名： | 唐一鸣 姜中其 陈俭 |
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| 作者单位： | 浙江大学农业部动物疫病病原学与免疫控制重点开放实验室,杭州,310029 |
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| 基金项目： | 国家蛋鸡产业技术体系项目 |
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| 摘 要： | 研究了乳酸恩诺沙星对小鼠的急性毒性,用寇氏法计算实验小鼠的半数致死量(LD50)和95%置信限。结果表明,乳酸恩诺沙星对小白鼠灌胃染毒及腹腔注射染毒的LD50分别为3579mg/kg和571.3mg/kg,其95%可信限分别为3011～4255mg/kg和498.3～655.1mg/kg。研究提示,乳酸恩诺沙星属低毒物质,其可溶性粉能用于开展药效试验。
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| 关 键 词： | 乳酸恩诺沙星 小鼠 急性毒性 |
Acute Toxicity Test of Enrofloxacin Lactate in Mice |
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| TANG Yi-ming,JIANG Zhong-qi,CHEN Jian. Acute Toxicity Test of Enrofloxacin Lactate in Mice[J]. Chinese Journal of Veterinary Drug, 2010, 44(4): 29-30,60 |
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| Authors: | TANG Yi-ming JIANG Zhong-qi CHEN Jian |
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| Affiliation: | TANG Yi-ming,JIANG Zhong-qi,CHEN Jian (Key Laboratory of Animal Epidemic Etiology & Immunological Prevention of Ministry of Agriculture,Zhejiang University,Hangzhou 310029,China) |
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| Abstract: | The acute toxicity of enrofloxacin lactate in mice was studied.LD50 values and its 95% confidence limits were calculated according to Karber method.The results showed that the LD50 of enrofloxacin lactate in mice ig and ip was 3 579 and 571.3 mg/kg,its 95% confidence limits were between 3 011 mg/kg and 4 255 mg/kg,498.3 mg/kg and 655.1 mg/kg,respectively.We concluded that enrofloxacin lactate is a safe antibacterial agent with low toxicity,and its soluble powder can be used in the following efficacy test. |
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| Keywords: | enrofloxacin lactate mice acute toxicity |
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