Precautions when using opioid agonist-antagonist analgesics.

Agonist-antagonists are attractive because of their availability and absence of strict regulation. They do provide effective analgesia in many cases, and they are cost-effective. Incomplete analgesia can be noted in moderate to severe pain. Cardiopulmonary depression may be noted following agonist-antagonist administration. Interference with coadministered opiate agents may occur.