Polyene Macrolactams from Marine and Terrestrial Sources: Structure,Production Strategies,Biosynthesis and Bioactivities |
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| Authors: | Wei Zhao Hong Jiang Xiao-Wan Liu Jian Zhou Bin Wu |
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| Affiliation: | 1.Polytechnic Institute, Zhejiang University, Hangzhou 310015, China;2.Fujian Provincial Key Laboratory of Screening for Novel Microbial Products, Fujian Institute of Microbiology, Fuzhou 350007, China; (H.J.); (J.Z.);3.The State Key Laboratory of Marine Pollution and Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR 999077, China;4.Ocean College, Zhejiang University, Zhoushan 321000, China |
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| Abstract: | Over the past few decades (covering 1972 to 2022), astounding progress has been made in the elucidation of structures, bioactivities and biosynthesis of polyene macrolactams (PMLs), but they have only been partially summarized. PMLs possess a wide range of biological activities, particularly distinctive fungal inhibitory abilities, which render them a promising drug candidate. Moreover, the unique biosynthetic pathways including β-amino acid initiation and pericyclic reactions were presented in PMLs, leading to more attention from inside and outside the natural products community. According to current summation, in this review, the chem- and bio-diversity of PMLs from marine and terrestrial sources are considerably rich. A systematic, critical and comprehensive overview is in great need. This review described the PMLs’ general structural features, production strategies, biosynthetic pathways and the mechanisms of bioactivities. The challenges and opportunities for the research of PMLs are also discussed. |
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| Keywords: | polyene macrolactams (PMLs) structural features acquisition strategies biosynthetic pathways mechanisms challenges and opportunities |
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