Recent Advances in the Synthesis of Marine-Derived Alkaloids via Enzymatic Reactions |
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| Authors: | Bi-Shuang Chen Di Zhang Fayene Zeferino Ribeiro de Souza Lan Liu |
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| Institution: | 1.School of Marine Sciences, Sun Yat-Sen University, Zhuhai 519082, China; (B.-S.C.); (D.Z.); (L.L.);2.Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519082, China;3.Centro Universitário Planalto do Distrito Federal, Universidade Virtual do Estado de São Paulo (UNIPLAN), Campus Bauru 17014-350, Brazil |
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| Abstract: | Alkaloids are a large and structurally diverse group of marine-derived natural products. Most marine-derived alkaloids are biologically active and show promising applications in modern (agro)chemical, pharmaceutical, and fine chemical industries. Different approaches have been established to access these marine-derived alkaloids. Among these employed methods, biotechnological approaches, namely, (chemo)enzymatic synthesis, have significant potential for playing a central role in alkaloid production on an industrial scale. In this review, we discuss research progress on marine-derived alkaloid synthesis via enzymatic reactions and note the advantages and disadvantages of their applications for industrial production, as well as green chemistry for marine natural product research. |
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| Keywords: | alkaloids natural product synthesis biotechnological approaches enzymatic reactions chemoenzymatic strategies |
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