Anticancer activity evaluation of kuanoniamines A and C isolated from the marine sponge Oceanapia sagittaria, collected from the Gulf of Thailand |
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Authors: | Kijjoa Anake Wattanadilok Rawiwan Campos Nair Nascimento Maria São José Pinto Madalena Herz Werner |
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Affiliation: | Anake Kijjoa, Rawiwan Wattanadilok, Nair Campos, Maria São José Nascimento, Madalena Pinto, and Werner Herz |
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Abstract: | The pyridoacridine alkaloids kuanoniamines A and C were isolated together with 24 α-methylcholestanol, p-hydroxybenzaldehyde, p-hydroxybenzoic acid, phenylacetic acid and 3-formylindole from the ethyl acetate extract of the marine sponge Oceanapia sagittaria (Sollas), collected from the Gulf of Thailand. Kuanoniamines A and C were evaluated for their effect on the growth of five human tumour and a non-tumour cell lines, as well as on the proliferation of human lymphocytes. Kuanoniamine A was found to be a potent growth inhibitor of all the tumour and a non-tumour cell lines while kuanoniamine C was less potent but showed high selectivity toward the estrogen dependent (ER+) breast cancer cell line. Kuanoniamine A has shown to be a more potent inhibitor of DNA synthesis than kuanoniamine C. Kuanoniamine A was also found to cause an extensive reduction of the MCF-7 cells in G2/M phase as well as an increase in the apoptotic cells. |
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Keywords: | Oceanapia sagittaria kuanoniamines A and C anticancer activity cell cycle progression apoptosis anti-proliferation of human lymphocytes |
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