The effect of transgenesis on rabbit thyroid tissue structure |
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Authors: | Tvrda E Massanyi P Lukac N Danko J Chrenek P |
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Institution: | Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Nitra, Slovakia. evina.tvrda@gmail.com |
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Abstract: | This study was aimed to compare structures of the thyroid tissue of transgenic rabbits expressing the human clotting factor VIII under the murine whey acidic protein promoter (mWAP-hFVIII rabbits) with the non-transgenic controls. Thyroid tissue samples were taken from transgenic and non-transgenic New Zealand White rabbits, examined by optical microscopy and analysed morphometrically. The analysis revealed no significant differences (P > 0.05) in the relative volume of basic thyroid structures. Furthermore, no significant differences (P > 0.05) were observed when measuring the epithelial height and nuclear diameter of the follicular cells. Altogether, this study demonstrates no negative effect of the mWAP-hFVIII transgenesis on the rabbit thyroid gland structure. |
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