Marginal excision of low-grade spindle cell sarcoma of canine extremities: 35 dogs (1996-2006) |
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Authors: | Stefanello Damiano Morello Emanuela Roccabianca Paola Iussich Selina Nassuato Claudia Martano Marina Squassino Chiara Avallone Giancarlo Romussi Stefano Buracco Paolo |
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Institution: | Departments of Veterinary Clinical Sciences and Veterinary Pathology, Hygiene and Public Health, School of Veterinary Medicine, University of Milan, Milan, Italy;;Department of Animal Pathology, School of Veterinary Medicine, University of Turin, Turin, Italy;and;Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Brescia, Italy |
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Abstract: | Objective— To evaluate recurrence rate and disease-free interval (DFI) of dogs with low-grade soft tissue spindle cell sarcoma of the extremities treated by marginal excision. Study Design— Retrospective study. Animals— Dogs (n=35) with soft tissue low-grade spindle cell sarcoma. Methods— Medical records were reviewed and dogs that had marginal surgical resection of low-grade soft tissue spindle cell sarcoma at or distal to elbow and stifle were included. Results— Histopathologic margins were dirty (12 dogs), clean but close (12), and clean (11). Follow-up after surgery occurred from 210 to 2202 days (minimum, 180 days). Local recurrence and metastatic rates were 10.8% and 0%, respectively. Median DFI and survival time were not reached, because <50% of dogs died of disease-related events. Mean DFI and mean survival time were 697.8 days (95% CI: 559.7–836 days) and 703.5 days (95% CI: 566.6–840.5 days), respectively. There were no significant differences among survival functions stratified by histologic margins. Conclusion— Marginal surgical excision without adjuvant treatment of low-grade soft tissue spindle cell sarcoma of the extremities results in a low local recurrence rate. Clinical Relevance— Low-grade spindle cell sarcomas located at or distal to the elbow and stifle joints can be excised without need for wide or radical surgery. |
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