伊维菌素浇泼剂对绵羊线虫的驱虫效力与安全性试验

应用0.5%伊维菌素浇泼剂按0.3,0.4,0.5mg/kg.b w剂量对绵羊沿背中线皮肤一次浇泼给药,并以伊维菌素注射剂0.2mg/kg.b w剂量做对照。结果:伊维菌素浇泼剂0.3mg/kg,0.4mg/kg.b w剂量对消化道线虫虫卵转阴率分别为85%和90%,减少率分别为89.1%和95.9%;对原圆科线虫幼虫转阴率分别为60%和75%,减少率分别为77.2%和86.7%;0.5mg/kg.b w剂量对消化道线虫虫卵转阴率和减少率均为100%,对原圆科线虫幼虫转阴率为85%,减少率为95.4%。解剖检查结果:伊维菌素浇泼剂三种剂量对绵羊消化道、呼吸道多属线虫均有效,总计驱虫率分别为90.8%,95.6%和99.7%,伊维菌素浇泼剂0.5mg/kg.b w剂量与伊维菌素注射剂0.2mg/kg.b w剂量驱虫效果基本一致;绵羊经皮给药可耐受1.0mg/kg.b w剂量。试验证明:伊维菌素浇泼剂经皮给药驱除绵羊线虫高效安全,临床推荐剂量以0.5mg/kg.b w为宜。

Effect and safe experiment of Pour-sprinkling preparation of Ivermectin for deworming nematode of sheep

The pour-sprinkling preparation of 0.5% Ivermectin in a dose of 0.3,0.4 and 0.5mg/kg.were given to sheep by means of single pour-sprinkling the skin along center line on bodyback of sheep.Ivermectin in a dose of 0.2mg/kg.was injected as control.The results showed that negative rate of nematode ova of alimentary canal in the sheep of 0.3mg/kg.and 0.4mg/kg.groups were 85% and 90%,and the reductive rate were 89.1% and 95.9%,respectively.The negative rate of protstrongylus larvae were 60% and 75%,and the reductive rate were 77.2% and 86.7%,respectively.The both negative rate and reductive rate of nematode ova of alimentary canal in the sheep of 0.5mg/kg.group were 100%,and the negative rate and reductive rate of protstrongylus larvae in dose 0.5mg/kg.were 85% and 95.4%,respectively.The results of amatomical examination showed that the three dose of Ivermectin pour-sprikling preparation had good effect for many nematodes in alimentary canal and breath canal of sheep,The total deworming were rate 90.8%,95.6% and 99.7%,respectively.The deworming effect dose 0.5mg/kg.of Ivermectin pour-sprikling preparation and 0.2mg/kg.injection was same.Shep can bear 1.0mg/kg.dose which given by skin,The experiment proved that Ivermectin pour-sprikling preparation was effective and safe for deworming nematode by means of giving medicine through skin.The clinical recommendation dosage.was 0.5mg/kg.