动物乳汁中瘦素的研究进展

为了更好的理解乳汁中瘦素的来源和功能，作者综述了在人等哺乳类动物的妊娠、泌乳阶段乳腺中leptin及其受体的基因表达，血液和乳中的瘦素含量。乳腺的多种组织能够表达leptin，其作为一种分泌因子,影响乳腺上皮细胞的生长分化；上皮细胞能够将leptin从血液中转运出来，这是leptin在乳中存在的主要原因。乳中的leptin蛋白可能对新生儿有生理作用。

The Function of Leptin on Milk

This paper reviews data on mammary leptin and leptin receptor gene expression as well as on biood and milk leptin levels during the pregnancy-lactation cycle in humans,rodents and ruminants with the aim of better understanding milk leptin origin and functions.The few published papers report that leptin may be produced by different cell types in the mammary tissue,and may act as a paracrine factor on mammary epithelial cell proliferation.In addition to leptin synthesis,epithelial cells may transfer leptin from the blood,and these two mechanisms may account for the presence of leptin in the milk.If leptin levels in milkare found to be significant,this hormne could be involved in neonate physiology.