Aminoaciduria Caused by Fanconi Syndrome in a Heifer |
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| Authors: | N Cesbron L Dorso A‐L Royer G Dervilly‐Pinel J Hervé |
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| Institution: | 1. Clinic for Ruminants, Oniris – Nantes‐Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, Loire‐Atlantique, France;2. Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), INRA, Oniris – Nantes‐Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, Loire‐Atlantique, France;3. Laboratoire d'Immuno‐Endocrinologie Cellulaire et Moléculaire, INRA, Oniris – Nantes‐Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, Loire‐Atlantique, France |
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| Abstract: | A case study of renal tubular dysfunction consistent with idiopathic Fanconi syndrome is reported in an 18‐month‐old Holstein heifer. The clinical, biochemical, and histopathological features are described. The heifer had clinical signs of growth retardation, wasting, and persistent diarrhea. Biochemical blood analysis identified hypokalemia, hyponatremia, and hypochloremia. Urinalysis identified glycosuria, proteinuria, and acidic pH. Histological examination of the kidney disclosed mild tubular necrosis with proteinaceous casts in the lumina of renal tubules. We performed LC‐HRMS on urine to confirm Fanconi syndrome. Using this technique, we identified severe generalized aminoaciduria suggestive of idiopathic renal Fanconi syndrome in this heifer. |
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| Keywords: | Cattle high‐resolution mass spectrometry liquid chromatography renal tubular dysfunction |
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