Disposition of a long‐acting oxytetracycline formulation in Thai swamp buffaloes (Bubalus bubalis) |
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| Authors: | S. Poapolathep K. Wongpanit K. Imsilp P. Tanhan N. Klangkaew M. Giorgi A. Poapolathep |
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| Affiliation: | 1. Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand;2. Faculty of Natural Resources and Agro‐Industry, Chalermphrakiat Sakon Nakhon, Province Campus, Kasetsart University, Sakon Nakhon, Thailand;3. Department of Veterinary Sciences, University of Pisa, San Piero a Grado, Italy |
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| Abstract: | The present study aimed to characterize the pharmacokinetic profile of oxytetracycline long‐acting formulation (OTC‐LA) in Thai swamp buffaloes, Bubalus bubalis, following single intramuscular administration at two dosages of 20 and 30 mg/kg body weight (b.w.). Blood samples were collected at assigned times up to 504 h. The plasma concentrations of OTC were measured by high‐performance liquid chromatography (HPLC). The concentrations of OTC in the plasma were determined up to 264 h and 432 h after i.m. administration at doses of 20 and 30 mg/kg b.w., respectively. The Cmax values of OTC were 12.11 ± 1.87 μg/mL and 12.27 ± 1.92 μg/mL at doses of 20 and 30 mg/kg, respectively. The AUClast values increased in a dose‐dependent fashion. The half‐life values were 52.00 ± 14.26 h and 66.80 ± 10.91 h at doses of 20 and 30 mg/kg b.w, respectively. Based on the pharmacokinetic data and PK–PD index (T > MIC), i.m. administration of OTC at a dose of 30 mg/kg b.w once per week might be appropriate for the treatment of susceptible bacterial infection in Thai swamp buffaloes. |
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