New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp. |
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| Authors: | Jinwei Ren Ruiyun Huo Gaoran Liu Ling Liu |
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| Institution: | 1.State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; (J.R.); (R.H.); (G.L.);2.College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100039, China |
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| Abstract: | Three new andrastin-type meroterpenoids penimeroterpenoids A–C (1–3) together with two known analogs (4 and 5) were isolated from the cultures of the marine-derived Penicillium species (sp.). The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of 1–3 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed moderate cytotoxicity against A549, HCT116, and SW480 cell lines. |
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| Keywords: | marine-derived fungus secondary metabolites meroterpenoids absolute configurations cytotoxicity |
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