Susceptibility of canine, feline and human erythrocytes to oxidant-mediated injury

e relative susceptibilities of feline, canine and human erythrocytes to in vitro hydrogen peroxide-induced lipid peroxidation and hemolysis were studied. At 15 minutes following exposure to hydrogen peroxide, cat erythrocytes had higher concentrations of lipid peroxidation by-products and a greater percent hemolysis as compared to dogs and humans. Erythrocytes from cats with induced sterile abscesses had lower concentrations of the antioxidant glutathione, but they did not have detectable concentrations of lipid peroxides nor were they more susceptible to in vitro lipid peroxidation or hemolysis.