Pharmacokinetics of doxycycline in dogs. |
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Authors: | R C Wilson D T Kemp J V Kitzman D D Goetsch |
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Affiliation: | Department of Physiology, College of Veterinary Medicine, Auburn University, Alabama 36849. |
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Abstract: | Six adult dogs were given doxycycline hyclate at a dosage of 5 mg/kg of body weight intravenously so that pharmacokinetic parameters could be evaluated. Serum doxycycline concentrations were determined over a 48 h period using a modified agar well bioassay. Compartmental pharmacokinetic evaluation of the serum concentration time data indicated that doxycycline has a half-life of 10.36 h, a body clearance of 1.68 +/- 0.44 mL/min/kg, and a volume of distribution at steady state of 1.468 +/- 0.237 L/kg. Doxycycline pharmacokinetics are favorable for therapeutic use in the dog. |
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