Occurrence of Spontaneous Tumors in the Central Nervous System (CNS) of F344
and SD Rats |
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Authors: | Mariko Nagatani Kayoko Kudo Seiki Yamakawa Toko Ohira Yuko Yamaguchi Shinichiro Ikezaki Isamu Suzuki Tsubasa Saito Toru Hoshiya Kazutoshi Tamura Kazuyuki Uchida |
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Institution: | 1. Hamamatsu Branch of Pathology Division, BOZO Research Center Inc., 164-2 Wada-cho, Higashi-ku, Hamamatsu, Shizuoka 435-0016, Japan;2. Pathology Division, Gotemba Laboratories, BOZO Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan;3. Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan |
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Abstract: | In order to accurately assess the carcinogenicity of chemicals with regard to rare
tumors such as rat CNS tumors, sufficient information about spontaneous tumors are very
important. This paper presents the data on the type, incidence and detected age of CNS
tumors in F344/DuCrlCrlj (a total of 1363 males and 1363 females) and Crl:CD(SD) rats (a
total of 1650 males and 1705 females) collected from in-house background data-collection
studies and control groups of carcinogenicity studies at our laboratory, together with
those previously reported in F344 and SD rats. The present data on F344/DuCrlCrlj rats
(F344 rats) and Crl:CD(SD) rats (SD rats) clarified the following. (1) The incidences of
all CNS tumors observed in F344 rats were less than 1%. (2) The incidences of malignant
astrocytoma and granular cell tumor were higher in male SD rats than in female SD rats.
(3) The incidences of astrocytoma and granular cell tumor were higher in SD rats than in
F344 rats. (4) Among astrocytoma, oligodendroglioma and granular cell tumor,
oligodendroglioma was detected at the youngest age, followed by astrocytoma, and
ultimately, granular cell tumor developed in both strains. The incidences observed in our
study were almost consistent with those previously reported in F344 and SD rats. |
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Keywords: | historical control data central nervous system tumor F344 rat SD rat |
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