Needle-free delivery of an inactivated avian influenza H5N3 virus vaccine elicits potent antibody responses in chickens |
| |
| Authors: | Oladele Ogunremi John Pasick Yohannes Berhane |
| |
| Affiliation: | Ottawa Laboratory Fallowfield, Canadian Food Inspection Agency, 3851 Fallowfield Road, Ottawa, Ontario K2H 8P9 (Ogunremi); National Centre for Foreign Animal Diseases, Canadian Food Inspection Agency, Winnipeg, 1015 Arlington Street, Winnipeg, Manitoba R3E 3M4 (Pasick, Berhane). |
| |
| Abstract: | A needle-free delivery system was assessed as a route for providing quick, safe, and effective vaccination against avian influenza (AI). Two groups of chickens were vaccinated with a commercially available inactivated H5N3 virus vaccine delivered either with a needle-free device or with the conventional syringe-and-needle method recommended by the vaccine manufacturer. The kinetic aspects of seroconversion, peak antibody levels, and antibody titers were measured by a combination of an indirect enzyme-linked immunosorbent assay and the hemagglutination-inhibition test and were all found to be similar in the 2 groups of chickens. We conclude that the needle-free delivery system could result in effective immunization against H5N1 AI epidemics and pandemics in chickens. |
| |
| Keywords: | |
|
|
