化痰脉通片对痰瘀型颈动脉粥样硬化患者血清ox-LDL和IL-6的调节作用观察

目的 观察化痰脉通片对痰瘀型颈动脉粥样硬化（carotid atherosclerosis，CAS）患者血清氧化型低密度脂蛋白（oxidative low-density lipoprotein，ox-LDL）及血清白细胞介素6（interleukin-6，IL-6）水平的调节作用。方法 将符合纳入标准的65例CAS患者随机分成对照组32例和治疗组33例，对照组采用阿司匹林肠溶片+阿托伐他汀钙片进行治疗；治疗组在对照组基础上联合化痰脉通片口服治疗。疗程6个月。观察比较两组治疗前后血清ox-LDL、IL-6水平和颈动脉内膜中层厚度（intima-media thickness，IMT）的变化。结果 治疗后两组血清ox-LDL水平均较治疗前降低，治疗组的变化差异有统计学意义（P<0.05），降低幅度显著大于对照组（P<0.05）；治疗后两组血清IL-6水平均较治疗前有所降低，但差异无统计学意义（P>0.05）；两组治疗前后IMT变化差异无统计学意义（P>0.05）。结论 对痰瘀型CAS患者采用化痰脉通片联合西药治疗可显著降低其血清ox-LDL水平，从而达到保护血管内皮的目的。

Observation on Regulating Effect of Huatan Maitong Tablets on Serum ox-LDL and IL-6 in Patients with Carotid Atherosclerosis of Phlegm Stasis Type

Objective To observe regulating effect of Huatan Maitong Tablets on oxidative low-density lipoprotein (ox-LDL) and interleukin-6 (IL-6) levels in patients with carotid atherosclerosis (CAS). Methods A total of 65 CAS patients meeting the inclusion criteria were randomly divided into control group (32 cases) and treatment group (33 cases). The control group was treated with aspirin enteric-coated tablets and atorvastatin calcium tablets; and the treatment group was additionally treated with Huatan Maitong Tablets orally on the treatment basis of the control group. The course of treatment was 6 months. Changes in serum levels of ox-LDL and IL-6, and carotid intima-media thickness (IMT) were observed and compared between the 2 groups before and after the treatment. Results After the treatment, the serum ox-LDL level in the 2 groups was decreased compared with that before the treatment, and the difference in the treatment group was statistically significant (P<0.05), with its decrease extent more obvious than that in the control group (P<0.05). After the treatment, the serum IL-6 level in the 2 groups was decreased compared with that before the treatment, but the difference was not statistically significant (P>0.05). There was no statistically significant difference in IMT between the 2 groups before and after the treatment (P>0.05). Conclusion Huatan Maitong Tablets combined with Western medicine can obviously decrease serum ox-LDL level in patients with CAS of phlegm stasis type, which can achieve the purpose of protecting vascular endothelium.