Preliminary investigations on the effects of a Strongylus vulgaris larval extract,mononuclear factors and platelet factors on equine smooth muscle cells in vitro |
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| Authors: | S. J. Morgan R. W. Storts P. C. Stromberg B. A. Sowa J. C. Lay |
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| Affiliation: | (1) Department of Veterinary Pathology, Texas A & M University, 77843 College Station, Texas, USA;(2) Present address: Department of Veterinary Pathology, College of Veterinary Medicine, Oklahoma State University, 74078 Stillwater, Oklahoma, USA;(3) Present address: Department of Pathobiology, The Ohio State University, 43210 Columbus, Ohio, USA |
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| Abstract: | Factors involved in the proliferation of equine vascular smooth muscle cells were studied in vitro. The most prominent proliferative responses in cultured vascular smooth muscle cells were induced by Strongylus vulgaris larval antigen extract (LAE) and platelet-derived factors. Less significant proliferative responses were obtained with conditioned media from S. vulgaris LAE stimulated and from unstimulated equine mononuclear leukocytes. Additionally, vascular smooth muscle cells exposed to S. vulgaris LAE developed numerous perinuclear vacuoles and were more spindle-shaped than control or smooth muscle cells exposed to other factors. Equine mononuclear leukocytes exposed to LAE developed prominent morphological changes, including enlargement, clumping and increased numbers of mitotic figures. |
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| Keywords: | horse in vitro proliferation leukocytes platelet smooth muscle Strongylus vulgaris |
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