Renal embryonal nephroma exhibiting malignant features in a Dutch rabbit (Oryctolagus cuniculus) |
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| Affiliation: | 1. Exoticsvet, Valencia, Spain;2. Highcroft Veterinary Referrals, Bristol, UK;3. International Zoo Veterinary Group, Keighley, UK;1. Clinic for Small Mammals, Reptiles and Birds, University of Veterinary Medicine, Hannover, Germany;2. Clinic of Small Animals, Posthausen, Germany;3. Institute for Biometry, Epidemiology and Information Processing, University of Veterinary Medicine, Hannover, Germany |
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| Abstract: | BackgroundBenign embryonal nephromas have been documented in rabbits. However, only one case of nephroblastoma with concurrent metastasis (pulmonary), a postmortem incidental finding, has been published.Case presentationA 3-year-old neutered male Dutch rabbit (Oryctolagus cuniculus) was referred for assessment of a firm mass located in the mid-dorsal abdomen. Abdominal ultrasonography confirmed a large soft tissue mass of suspected renal origin. A left-sided nephrectomy was performed via a ventral midline approach. Multiple white macular lesions, hyperemia, and petechiae were observed in the mesenteric fat surrounding the spleen. Histopathological examination of the abnormal kidney and the mesenteric fat revealed microscopic findings consistent with an embryonal nephroma exhibiting distinct features of malignancy. At 6- and 12-month postsurgery, ultrasonographic evidence of tumor recurrence was not observed.Conclusion and case relevanceThis is the first report of successful treatment of an embryonal nephroma showing malignant behavior and metastasis to the surrounding adipose tissue with a minimum postoperative survival time of 12 months and no ultrasonographic evidence of local recurrence. |
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