Effects of oral cisapride administration in chinchillas (Chinchilla lanigera) with experimentally induced fecal output reduction |
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| Affiliation: | 1. Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA;2. Tufts Clinical and Translational Science Institute, Tufts Medical Center, Tufts University, Boston, MA, USA;1. Small Animal Clinic, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany;2. Institute of Veterinary Pathology, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany;1. The Center for Bird and Exotic Animal Medicine, WA 98011, USA.;2. Bridge Animal Referral Center, WA, USA;3. Institute of Veterinary Pathology, Freie Universität Berlin, Germany;4. Institute of Pathology, University of Veterinary Medicine, Vienna, Austria;5. Michigan State University, Department of Pathobiology and Diagnostic Investigation, East Lansing, MI, USA;6. Michigan State University, College of Veterinary Medicine, Veterinary Diagnostic Laboratory, Lansing, MI, USA;7. ZNLabs, Salt Lake City, UT, USA;1. Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO;2. Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO |
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| Abstract: | BackgroundCisapride, a prokinetic drug, has been anecdotally recommended in chinchillas at a dose of 0.5 mg/kg PO q8-12h to treat gastrointestinal hypomotility. However, studies in other rodent species suggest that higher doses are necessary to be effective.MethodsIn two randomized, placebo-controlled, blinded, crossover studies, the effects of cisapride (10 mg/kg PO q12h for four doses), administered with or without concurrent syringe feeding of a critical care formula (25 mL/kg PO q12h for two doses) were evaluated in chinchillas following recovery from sedation induced by alfaxalone-butorphanol. Food intake and fecal output were quantified to assess the effects of cisapride on these parameters.ResultsOver the first 24 hours after recovery from sedation, animals that received cisapride and syringe feeding had the least reduction in fecal output (-27 ± 23%) compared to the control treatment (-48 ± 22%, P = 0.008) or to animals which received syringe feedings alone (-40 ± 23%, P = 0.12). Cisapride administered without concurrent syringe feedings had no effect on fecal output. No adverse effects were recorded following the administration of cisapride.Conclusions and clinical relevanceThe oral administration of cisapride at 10 mg/kg q12h in conjunction with syringe feeding resulted in a slight, but not clinically relevant, attenuation of fecal output reduction by ~13% compared to syringe feedings alone and by ~20% compared to no treatment. Without the concurrent administration of syringe feedings, cisapride had no effect on fecal output in chinchillas. |
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