Disposition of firocoxib in late pregnant and early postpartum mares |
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| Authors: | S Giguère ML Macpherson SM Benson S Cox JW McNaughten MA Pozor |
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| Institution: | 1. Department of Large Animal Medicine, University of Georgia, Athens, GA, USA;2. Department of Large Animal Clinical Sciences, University of Florida, Gainesville, FL, USA;3. Department of Biomedical and Diagnostic Sciences, University of Tennessee, Knoxville, TN, USA |
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| Abstract: | Pregnancy induces several physiologic changes that might impact the bioavailability, distribution, metabolism, and excretion of drugs. The objective of this study was to determine the effects of pregnancy on the disposition of oral firocoxib in mares. Seven pony mares received oral firocoxib paste at a dose of 0.1 mg/kg during late pregnancy and again 12 to 33 days postpartum. Firocoxib concentrations were measured in plasma by HPLC with ultraviolet detection. Maximum plasma concentrations were significantly lower in pregnant (50.0 ± 21.8 ng/mL) than in postpartum (73.7 ± 25.6 ng/mL) mares. Plasma concentrations 24 h after administration, time to maximum plasma concentrations, and area under the plasma concentration versus time curve were not significantly different between late pregnancy and the postpartum period in mares. |
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