Bmp/Smad信号通路及其在哺乳动物卵巢发育中的作用

开展绵羊多羔性状基因的研究对于揭示其分子调控机制和提高绵羊繁殖力具有重要意义。骨形态发生蛋白(BMPs)为转化生长因子-β(TGF-β)超家族成员,与哺乳动物繁殖活动密切相关。研究表明,BMPs可促使原始卵泡向次级卵泡转化,对哺乳动物卵巢颗粒细胞增殖、生殖激素的合成和分泌以及卵母细胞成熟和排卵等方面起重要调节作用,而BMPs发挥功能主要依赖于经典的Bmp/Smad信号通路。本文就Bmp/Smad信号通路成员的表达、对早期胚胎发育的影响以及在哺乳动物卵巢发育中的作用等方面的研究进行总结,以期为进一步研究BMPs及其信号通路的调控机制提供参考。

Bmp/Smad Signaling Pathway and Its Role in Mammalian Ovarian Development

It is of great significance to improve the reproductive performance of sheep and reveal its molecular mechanism to research the genes affecting sheep fecundity. The largest subfamily of the transforming growth factor-β(TGF-β) superfamily is bone morphogenetic proteins(BMPs), which are closely related to mammalian reproductive activities. BMPs can promote the transformation of primordial follicles into secondary follicles, and play an important role in regulating mammalian ovarian granulosa cell proliferation, synthesis and secretion of reproductive hormones, and oocyte maturation and ovulation. While BMPs function mainly depending on the classical Bmp/Smad signaling pathway. This review summarizes the expression of the Bmp/Smad signaling pathway members, effects on early embryo development, and their role in mammalian ovarian development, which will provide a useful reference for further study of its regulatory functions.