| 奶牛乳腺炎致病机制的表观遗传调控研究进展 |
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| 引用本文： | 张晓建,赵俭,张伟,安志兴,王三虎,白跃宇.奶牛乳腺炎致病机制的表观遗传调控研究进展[J].中国畜牧杂志,2019(1):22-28. |
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| 作者姓名： | 张晓建 赵俭 张伟 安志兴 王三虎 白跃宇 |
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| 作者单位： | 1.河南科技学院动物科技学院;2.河南省畜牧局动物卫生监督所 |
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| 基金项目： | 河南省基础与前沿技术研究计划(152300410095;132300410014);NSFC-河南人才培养联合基金(U1504306);2014年度高层次人才科研启动项目(206010615007) |
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| 摘 要： | 奶牛乳腺炎作为制约奶牛养殖业发展的主要疾病之一,其受到环境、理化因素以及不同病原菌等多种因素影响。表观遗传调控作为一种新的分子调控机制,在奶牛乳腺炎致病过程中起着十分重要的作用。本文拟从DNA甲基化、组蛋白修饰和非编码RNA等多方面综述其在奶牛乳腺炎发生、发展中的作用,并从多维度提出奶牛乳腺炎表观遗传调控机制未来研究策略,以期为奶牛乳腺炎致病机制研究以及有效防控提供参考。
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| 关 键 词： | 奶牛乳腺炎 表观遗传调控 DNA甲基化 组蛋白修饰 非编码RNA |
Progress on Epigenetic Regulation of the Pathogenesis of Cow Mastitis |
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| ZHANG Xiao-jian,ZHAO Jian,ZHANG Wei,AN Zhi-xing,WANG San-hu,BAI Yue-yu.Progress on Epigenetic Regulation of the Pathogenesis of Cow Mastitis[J].Chinese Journal of Animal Science,2019(1):22-28. |
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| Authors: | ZHANG Xiao-jian ZHAO Jian ZHANG Wei AN Zhi-xing WANG San-hu BAI Yue-yu |
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| Institution: | ,School of Animal Science, Henan Institute of Science and Technology,Animal Health Supervision of Henan Province,Bureau of Animal Husbandry of Henan Province |
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| Abstract: | As one of the main diseases that impede the development of dairy cattle farming industry, cow mastitis is deeply influenced by environmental, physicochemical factors and different pathogenic bacteria. Epigenetic regulation, being a new molecular regulation mechanism, plays a very important role in the pathogenesis of cow mastitis. Here, the roles of DNA methylation, histone modification and non-coding RNA in the occurrence and development of cow mastitis were reviewed, and the future research strategies of the epigenetic regulation mechanism of cow mastitis were proposed in multi-dimension, in order to provide references for the pathogenesis research and effective prevention and control of cow mastitis. |
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| Keywords: | Cow mastitis Epigenetic regulation DNA methylation Histone modification Non coding RNA |
| 本文献已被 CNKI 维普 等数据库收录！ |
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