乙酰辅酶A酰基转移酶1基因研究进展 |
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作者单位: | ;1.延边大学农学院;2.吉林省农业科学院畜牧分院 |
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摘 要: | 乙酰辅酶A酰基转移酶1(ACAA1)基因编码硫解酶家族的酶,属于酰基辅酶A代谢酶超家族中的硫解酶家族。ACAA1分布在过氧化物酶体中,通过催化β-氧化途径的最后一步参与脂肪酸的延伸和降解,是细胞脂代谢过程中一个重要调控基因。本文综述了ACAA1基因的结构、表达、分子机制及其所参与的相关代谢反应。
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关 键 词: | 乙酰辅酶A酰基转移酶1 硫解酶 过氧化物酶体 脂代谢 |
Advance in Acetyl-CoA acyltransferase 1 Gene |
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Affiliation: | ,College of Agronomy, Yanbian University,Animal Husbandry Division, Jilin Academy of Agricultural Sciences |
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Abstract: | The acetyl-CoA acyltransferase 1(ACAA1) gene encodes the thiolase family of enzymes, which belongs to the thiolase family of the acyl-CoA metabolic enzyme superfamily. It is distributed in peroxisomes and involved in the extension and degradation of fatty acids by catalyzing the last step of the beta-oxidation pathway; It is an important regulatory gene in the process of cell lipid metabolism. In this article, the structure, expression, molecular mechanisms and related metabolic reactions of the ACAA1 gene were reviewed. |
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Keywords: | Acetyl-CoA acyltransferase 1 Thiolase Peroxisome Lipid metabolism |
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