Third degree atrioventricular block and sudden death secondary to acute myocarditis in a dog |
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| Institution: | 1. Department of Veterinary Clinical Medicine, Matthew J. Ryan Veterinary Hospital, 3900 Delancey Street, Philadelphia, PA 19104, USA;2. Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, 105 Magruder Hall, Corvallis, OR 97331, USA;3. Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL 61802, USA;1. Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Sapporo, Hokkaido 060-0818, Japan;2. Veterinary Teaching Hospital, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Sapporo, Hokkaido 060-0818, Japan;3. Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, 1-1 Gakuenkibanadai-nishi, Miyazaki 889-2192, Japan;1. Unité de Cardiologie d''Alfort (UCA), Université Paris-Est, École Nationale Vétérinaire d''Alfort, Centre Hospitalier Universitaire Vétérinaire d''Alfort (CHUVA), 7 Avenue Du Général de Gaulle, Maisons-Alfort, F-94700, France;2. Ecole Nationale Vétérinaire d''Alfort, Univ Paris Est Creteil, INSERM, IMRB, F-94700 Maisons-Alfort, France;3. Centre Hospitalier Vétérinaire des Cordeliers, 29 Avenue Du Maréchal Joffre, 77100, Meaux, France;4. Department of Pharmacology-Toxicology, École Nationale Vétérinaire d''Alfort, Centre Hospitalier Universitaire Vétérinaire d''Alfort (CHUVA), 7 Avenue Du Général de Gaulle, Maisons-Alfort, F-94700, France;5. Department of Biostatistics and Clinical Epidemiology, Université Paris-Est, École Nationale Vétérinaire d''Alfort, 7 Avenue Du Général de Gaulle, Maisons-Alfort, F-94700, France;1. Division of Cardiology, Clinic for Small Animal Internal Medicine, Vetsuisse Faculty University of Zürich, Switzerland;2. Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Italy |
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| Abstract: | Third degree atrioventricular (AV) block in dogs is thought to be most frequently characterized by non-specific fibrotic changes in the AV node. However, it may occur secondary to an undiagnosed inflammatory process. We report a case of third degree AV block in a dog, secondary to acute lymphocytic-plasmacytic myocarditis that resulted in sudden death. This dog had cardiac troponin I levels of 44.65 ng/mL (normal <0.11 ng/mL). The serum cardiac troponin I level was five times higher than any other AV block patient measured in our laboratory, and was also substantially higher than in dogs with chronic valve disease or dilated cardiomyopathy. The severe myocardial necrosis observed at necropsy correlated with the degree of cardiac troponin I elevation. This report suggests that measurement of cardiac troponin I may be an indicated test before pacemaker implantation in dogs with third degree AV block. |
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