|
|||||
|
|
Indole-3-carbaldehyde: a tyrosinase inhibitor from fungus YL185 |
|
| Authors: | Kuniyoshi Shimizu Xinglian Geng Mika Hashiguchi Hiroto Suhara Syoko Fukunaga Seiji Yasutake Ryuichiro Kondo Mototake Tsutsui Ikuo Sato |
| Affiliation: | (1) Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan;(2) Chisso Corporation, Yokohama, 236-8605, Japan |
| Abstract: | Indole-3-carbaldehyde (1) was isolated as a tyrosinase inhibitor from the ethyl acetate-soluble fraction of extracellular fluids of unknown fungus YL185. The partial sequencing data of 18S ribosomal DNA (18S rDNA) indicate that this isolate belongs to the family Polyporaceae or Corticiaceae sensu lato. Indole-3-carbaldehyde inhibited the oxidation of l-3,4-dihydroxyphenylalanine (l-DOPA) by mushroom tyrosinase with a 50% inhibitory concentration (IC50) of 1.3 mM and showed inhibitory activity on melanin production in B16 melanoma cells. The aldehyde group of 1 plays an important role in eliciting tyrosinase inhibitory activity. |
| Keywords: | Tyrosinase Melanin Inhibitor Indole-3-carbaldehyde Fungus |
| 本文献已被 SpringerLink 等数据库收录！ | |