Genotyping of exercise-induced collapse in Labrador retrievers using an allele-specific PCR |
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Authors: | Takanosu Masamine Mori Hirokazu Suzuki Hiroetsu Suzuki Katsushi |
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Institution: | Nasunogahara Animal Clinic, 2-3574-98, Asaka, Ohtawara-shi, Tochigi 324-0043, Japan. mtakanosu@hotmail.com |
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Abstract: | Exercise-induced collapse (EIC) is an autosomal recessive disorder in Labrador retrievers. In this study, an allele-specific PCR was developed to detect the point mutation G767T in exon 6 of canine DNM1, previously shown to be responsible for canine EIC. Of 133 Labrador retrievers tested in Japan, 6 (4.5%) were homozygous (EIC) and 50 (37.6%) were heterozygous (carriers) for the G767T mutation. |
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