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| 维他昔布咀嚼片体外溶出度的测定 | |
| 引用本文： | 宋颂,侯文彬. 维他昔布咀嚼片体外溶出度的测定[J]. 中国兽药杂志, 2013, 47(2): 27-30 |
| 作者姓名： | 宋颂 侯文彬 |
| 作者单位： | 1. 天津中医药大学,天津,300193 2. 天津药物研究院,天津,300193 3. 北京欧博方医药科技有限公司,北京,100085 |
| 基金项目： | 北京市海淀区科技发展计划（K20110114C） |
| 摘 要： | 为了建立了维他昔布咀嚼片体外溶出度的测定方法,以0.8％十二烷基硫酸钠溶液为溶出介质,采用桨法(50 r/min),用紫外-可见分光光度法测定溶出度.结果显示,维他昔布浓度在0.002496 ～0.017472 mg/mL范围内,与吸收度呈良好的线性关系(r=0.9995),加样回收率为102.9％(RSD为1.36％),三批样品30 min时溶出度在80％以上.建立的溶出度测定方法重现性,均一性良好,样品溶出度大于80％,可用于维他昔布咀嚼片中溶出度的测定. |
| 关 键 词： | 维他昔布咀嚼片 溶出度 紫外-可见分光光度法 |
| 收稿时间： | 2012-10-08 |
| 修稿时间： | 2012-11-06 |
Determination of the Dissolution of Vitacoxib Chewable Tablets |
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| SONG Song , HUA Jie , ZHOU Fu-jun , LV Peng-yue , SUN Yan-jin , HOU Wen-bin. Determination of the Dissolution of Vitacoxib Chewable Tablets[J]. Chinese Journal of Veterinary Drug, 2013, 47(2): 27-30 | |
| Authors: | SONG Song HUA Jie ZHOU Fu-jun LV Peng-yue SUN Yan-jin HOU Wen-bin |
| Affiliation: | Tianjin University of Traditional Chinese Medicine, |
| Abstract: | The article established a method to determine the dissolution of vitacoxib chewable tablets. The dissolution was tested with the slurry method (50 r/min) in 0.8% sodium dodecyl sulfate solution as medium. The concentration of vitacoxib chewable tablets, determined by ultraviolet - visible spectrophotometry, showed a good linear relationship (r=0.9995) in the range of 0.002496 ~ 0.017472 mg/mL, and a satisfactory recovery rate as 102.9% (RSD=1.36%). The dissolution of three batches of samples was above 80% in 30 min. Therefore, the method can be used for determining the dissolution of vitacoxib chewable tablets, with good reproducibility and uniformity. |
| Keywords: | vitacoxib chewable tablets dissolution ultraviolet - visible spectrophotometry |
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