| 精氨酰甘氨酰天门冬氨酸三肽的合成 |
| |
| 引用本文： | 刘洪英,徐红岩,周乐.精氨酰甘氨酰天门冬氨酸三肽的合成[J].西北农业学报,2007,16(2):203-205. |
| |
| 作者姓名： | 刘洪英 徐红岩 周乐 |
| |
| 作者单位： | 1. 西北农林科技大学生命科学学院,陕西杨凌,712100
2. 中国科学院上海有机化学研究所,上海,200032 |
| |
| 摘 要： | 以L-精氨酸、L-甘氨酸、L-天门氨酸为原料,采用二环己基碳二亚胺(DCC)法合成了Arg-Gly-Asp(RGD)。Z-Arg(NO2)-OH经偶联剂活化与H-Gly-OMe.HCl缩合,水解后得到Z-Arg(NO2)-Gly-OH;产物与H-Asp(OBzl)-OBzl.TosOH偶联得到全保护多肽,经Pd-C/H2还原为Arg-Gly-Asp。
|
| 关 键 词： | 精氨酰甘氨酰天冬氨酸 三肽 偶联 二环己基碳二亚胺 |
| 文章编号： | 1004-1389（2007）02-0203-03 |
| 收稿时间： | 2006-09-21 |
| 修稿时间： | 2006-10-25 |
Synthesis of Tripeptide-RGD |
| |
| LIU Hong-ying,XU Hong-yan and ZHOU Le.Synthesis of Tripeptide-RGD[J].Acta Agriculturae Boreali-occidentalis Sinica,2007,16(2):203-205. |
| |
| Authors: | LIU Hong-ying XU Hong-yan and ZHOU Le |
| |
| Institution: | College of Life Sciences, Northwest A & F University, Yangling Shaanxi 712100 China;Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;College of Life Sciences, Northwest A & F University, Yangling Shaanxi 712100 China |
| |
| Abstract: | Takintg L-Arginine,L-Glycine and L-Aspartate as a raw material,used DCC coupling method to synthesize Arg-Gly-Asp(R GD).Activating by coupling reagent,Z-Arg (NO2)-OH was coupled with H-GIy-OMe·HCl,after the hydrolysis Z-Arg(NO2)-Gly-OH was obtained;and then it was reacted with H-Asp (OBzl)-OBzl·TosOH to get complete protected tripeptide,at last using Pd C/H2 as reducing reagent,the final product Arg-Gly-Asp was obtained. |
| |
| Keywords: | Arg-Gly-Asp(RGD) Tripeptide Couple DCC |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《西北农业学报》浏览原始摘要信息 |
| 点击此处可从《西北农业学报》下载免费的PDF全文 |
|
