| 蒲公英提取物对急性肺损伤小鼠炎症介质及SOD含量的影响 |
| |
| 引用本文： | 刘利本,平家奇,李佳佳,刘妍,王韵篪,张雪梅.蒲公英提取物对急性肺损伤小鼠炎症介质及SOD含量的影响[J].安徽农业科学,2010,38(17):9007-9007,9056. |
| |
| 作者姓名： | 刘利本 平家奇 李佳佳 刘妍 王韵篪 张雪梅 |
| |
| 作者单位： | 延边大学农学院动物医学系,吉林龙井,133400;延边大学农学院动物医学系,吉林龙井,133400;延边大学农学院动物医学系,吉林龙井,133400;延边大学农学院动物医学系,吉林龙井,133400;延边大学农学院动物医学系,吉林龙井,133400;延边大学农学院动物医学系,吉林龙井,133400 |
| |
| 基金项目： | 吉林省教育厅科研项目 |
| |
| 摘 要： | 目的]研究蒲公英水提物对脂多糖LPS诱导小鼠急性肺损伤（ALI）炎症介质及抗氧化能力的影响。方法]LPS滴鼻建立小鼠ALI模型,设空白组、模型组、蒲公英剂量（2.5、5.0、10.0 mg/kg）组和地塞米松（0.5 mg/kg）组。测定肺组织中超氧化物岐化酶SOD含量,检测肺泡支气管灌洗液中INF-γ、NO、PGE2含量。结果]蒲公英水提物可增强LPS诱导的ALI小鼠肺组织SOD的释放,降低BALF中炎症介质INF-γ、NO、PGE2的含量。结论]为蒲公英的开发利用提供理论依据。
|
| 关 键 词： | 蒲公英 脂多糖 急性肺损伤 炎症介质 SOD |
The Effects of Dandelion on Inflammatory Mediators and SOD in Mice with Acute Lung Injury |
| |
| LIU Li-ben et al.The Effects of Dandelion on Inflammatory Mediators and SOD in Mice with Acute Lung Injury[J].Journal of Anhui Agricultural Sciences,2010,38(17):9007-9007,9056. |
| |
| Authors: | LIU Li-ben |
| |
| Institution: | LIU Li-ben et al(Department of Animal Medicine,Agricultural College of Yanbian University,Longjing,Jilin 133400) |
| |
| Abstract: | Objective]The aime was to study the effects of of aqueous extract of dandelion on inflammatory mediators and anti-oxidative capacity in mice with acute lung injury induced by lipopolysaccharide.Method] Models of ALI were established by intranasal instillation of LPS,mice were randomly divided into control group,model group,dandelion(2.5,5.0,10.0 mg/kg) groups and dexamethasone(0.5 mg/kg) group.SOD activity of the lung tissues was determined,INF-γ,NO and PGE2 levels in bronchoalveolar lavage fluid(BALF) were measured.Result] The results showed that different concentrations of aqueous extract of dandelion could enhance the release of SOD in lung tissues,and decreased the content of information media of INF-γ,NO and PGE2 levels in BALF in ALI mice.Condusion]The study provided the theovetical basis for the development and utilization of dandelion. |
| |
| Keywords: | SOD |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
