Atipamezole in the management of detomidine overdose in a pony |
| |
Authors: | Di Concetto Stefano Michael Archer R Sigurdsson Sigurdur F Clarke Kw |
| |
Institution: | The Royal Veterinary College, Hawkshead Lane, Hatfield, Herts, UK. |
| |
Abstract: | OBSERVATIONS: A pony undergoing elective castration accidentally received an overdose of IV detomidine (200 microg kg(-1)) before anaesthesia was induced with ketamine and midazolam. A further 100 microg kg(-1) IV dose of detomidine was administered during anaesthesia. The mistake was recognized only when the animal failed to recover from anaesthesia in the expected time. The overdose (300 microg kg(-1) in total) was treated successfully with atipamezole, initially given IV and subsequently IM and titrated to effect to a total dose of 1100 microg kg(-1). The pony regained the standing position. A further injection of atipamezole (76 microg kg(-1) IM) was given 5 hours later to counteract slight signs of re-sedation. CONCLUSIONS: Atipamezole proved an effective antagonist for detomidine in a pony at an initial dose 3.65 x and a final total dose 3.9 x greater than the alpha2 agonist. |
| |
Keywords: | antagonism atipamezole detomidine horse overdose |
本文献已被 ScienceDirect PubMed 等数据库收录! |