| 雄激素对去势大鼠弓状核AR蛋白表达的影响 |
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| 引用本文： | 田光明,范光丽.雄激素对去势大鼠弓状核AR蛋白表达的影响[J].长江大学学报,2009(4):44-45,57. |
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| 作者姓名： | 田光明 范光丽 |
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| 作者单位： | [1]长江大学动物科学学院,湖北荆州434023 [2]西北农林科技大学动物科技学院,陕西杨陵712100 |
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| 摘 要： | 为了探讨雄激素（androgen）对去势大鼠弓状核（ARC）内雄激素受体（AR）表达的影响。将30只3月龄雄性健康SD大鼠随机分为GM组（睾丸摘除组）、IMC组（假手术组）、GM＋T组（睾丸摘除并用睾酮替代组），注射雄激素4周后灌注取材。结果表明，睾九摘除组大鼠弓状核内AR蛋白的表达显著减少，睾丸摘除并用睾酮替代组大鼠弓状核内AR蛋白的表达接近正常水平。说明去睾丸大鼠由于缺乏内源性雄激素，引起弓状核内AR蛋白表达减少，而补充外源性雄激素可抑制这一变化。
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| 关 键 词： | 去势 雄激素受体 雄激素 弓状核 |
Effects of Testosterone on Androgen Receptors of Arcuate Nucleus in Rat |
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| TIAN Guang-ming FAN Guang-li College of Animal Science , Technology,Northwest Agriculture , Forestry University,Yangling,Shaanxi ,China.Effects of Testosterone on Androgen Receptors of Arcuate Nucleus in Rat[J].Journal of Yangtze University,2009(4):44-45,57. |
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| Authors: | TIAN Guang-ming FAN Guang-li College of Animal Science Technology Northwest Agriculture Forestry University Yangling Shaanxi China |
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| Institution: | TIAN Guang-ming (College of Animal Science,Yangtze University,Jingzhou,Hubei 434025,China) FAN Guang-li College of Animal Science , Technology,Northwest Agriculture , Forestry University,Yangling,Shaanxi 712100,China |
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| Abstract: | To investigate the effect of testosterone on expression of androgen receptors(AR) in arcuate nucleus of castration rats,30 SD rats (3 months old) were randomly divided into GM,IMC and GM+T groups. GM group was castration group,IMC group was control group and GM+T group was AR replacement group. All rats were sacrificed after 4 weeks. The results showed that the immunoreactive production level of androgen receptors were decreased in GM group. After being treated with testosterone,the immunoreactive productio... |
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| Keywords: | castration androgen receptors testosterone acruate nucleus |
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