Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora |
| |
Authors: | Fagarasan Sidonia Muramatsu Masamichi Suzuki Keiichiro Nagaoka Hitoshi Hiai Hiroshi Honjo Tasuku |
| |
Institution: | Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. |
| |
Abstract: | Activation-induced cytidine deaminase (AID) plays an essential role in class switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin genes. We report here that deficiency in AID results in the development of hyperplasia of isolated lymphoid follicles (ILFs) associated with a 100-fold expansion of anaerobic flora in the small intestine. Reduction of bacterial flora by antibiotic treatment of AID-/- mice abolished ILF hyperplasia as well as the germinal center enlargement seen in secondary lymphoid tissues. Because an inability to switch to immunoglobulin A on its own does not lead to a similar phenotype, these results suggest that SHM of ILF B cells plays a critical role in regulating intestinal microflora. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|