| 防御素肽研究进展 |
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| 引用本文： | 屠利民,彭开松,王莹莹,祁克宗. 防御素肽研究进展[J]. 中国畜牧兽医, 2010, 37(9): 204-206 |
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| 作者姓名： | 屠利民 彭开松 王莹莹 祁克宗 |
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| 作者单位： | （1.安徽农业大学动物科技学院，合肥 230036； 2.河南科技大学动物科技学院，洛阳 471003） |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 防御素是近年来发现的一类具有广谱抗微生物活性的阳离子小肽,由38～100个氨基酸残基组成,且分子内富含二硫键,在天然性免疫和获得性免疫中发挥着重要的作用。由于其具有牢固的分子骨架、广泛的分布及生物活性功能,通过研究开发其在药用方面的价值,为人们替代传统抗生素提供了新途径。作者简述了防御素的结构特征与功能、分布、生物学活性、模拟肽的设计及应用前景。
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| 关 键 词： | 防御素 结构特征与功能 生物学活性 模拟肽的设计 |
The Advance on Investigation of Defensins Peptide |
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| TU Li-min,PENG Kai-song,WANG Ying-ying,QI Ke-zong. The Advance on Investigation of Defensins Peptide[J]. China Animal Husbandry & Veterinary Medicine, 2010, 37(9): 204-206 |
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| Authors: | TU Li-min PENG Kai-song WANG Ying-ying QI Ke-zong |
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| Affiliation: | （1.College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China;2.College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China) |
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| Abstract: | Defensins are found in recent years a class of broad-spectrum anti-microbial activity of cationic peptides from 38 to 100 amino acid residues and intramolecular disulfide bond rich in natural immunity and acquired immunity play important role, because of its strong molecular skeleton, a broad distribution and biological activity of the above research and development of its medicinal value, for the people an alternative to traditional antibiotics provides a new way. This paper describes the structural features of defensins and function, distribution, biological activity, peptide analog design and application. |
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| Keywords: | defensins structure and function biological activity design of analog peptides |
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