Pharmacokinetic study of oxytetracycline in healthy and vibriosis-infected ayu (Plecoglossus altivelis) |
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| Institution: | 1. Agronomy and Soil Science Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India;2. Analytical Chemistry Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 26015, Uttar Pradesh, India;3. Molecular Bioprospection Department of Biotechnology Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India;1. Postgraduate Student, Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan;2. Senior Assistant Professor, Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan;3. Professor and Chairman, Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan;1. University of Vienna, Department of Theoretical Biology, Althanstrasse 14, 1090 Vienna, Austria;2. Natural History Museum in Vienna, Ichthyological Collection, Burgring 7, 1010 Vienna, Austria;1. Department of Life Sciences, Cheng Kung University, Tainan 701, Taiwan;2. Taiwan Endemic Species Research Institute, ChiChi, Nantou 552, Taiwan;3. Department of Industrial Management, National Taiwan University of Science and Technology, Taipei 10607, Taiwan;4. Tainan Hydraulics Laboratory, National Cheng Kung University, Tainan 709, Taiwan;5. Department of Environmental Engineering and Science, Feng Chia University, Taichung 407, Taiwan;6. The Affiliated School of National Tainan First Senior High School, Tainan 701, Taiwan |
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| Abstract: | The pharmacokinetics and bioavailability of oxytetracycline (OTC) were examined in healthy and vibriosis-infected ayu (Plecoglossus altivelis). Water temperature was maintained at 18.0 ± 0.3 °C in all experiments. Serum concentrations of OTC in healthy fish after intravascular administration (25 mg kg−1 body weight) were best described by a two-compartment model, whereas serum concentration-time curves after oral administration (100 mg kg−1 body weight) in healthy and infected ayu could not be fitted by the nonlinear least squares method using one- and two-compartment models with first-order absorption. The estimated bioavailability after oral administration was 9.3% for healthy fish and 3.8% for infected fish. The elimination half-lives of serum, muscle, liver and kidney were 53.1 h, 106 h, 125 h and 117 h for healthy fish, and 63.2 h, 92.9 h, 107 h and 123 h for infected fish, respectively. A significant difference in bioavailability was revealed between healthy fish and infected fish, whereas elimination was similar in both fish. Serum protein binding in vivo of OTC was 68.0 ± 2.8% for healthy fish and 69.9 ± 4.4% for infected fish. |
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