| 高效液相色谱法测定硫酸安普霉素有关物质 |
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| 引用本文： | 吴宁鹏.高效液相色谱法测定硫酸安普霉素有关物质[J].中国兽药杂志,2009,43(11):33-36. |
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| 作者姓名： | 吴宁鹏 |
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| 作者单位： | 河南省兽药监察所,郑州,450008 |
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| 摘 要： | 建立了硫酸安普霉素有关物质测定的高效液相色谱法。硫酸安普霉素有关物质经磺酸基键合硅胶柱分离,茚三酮溶液衍生后,568 nm处测定。结果显示,测得的硫酸安普毒素8种有关物质得到良好分离。对硫酸安普霉素及其制剂测定结果表明,该方法适合硫酸安普霉素有关物质的测定。
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| 关 键 词： | 硫酸安普霉素 有关物质 高效液相色谱法 柱后衍生 |
| 收稿时间： | 2009/4/22 0:00:00 |
| 修稿时间： | 2009/6/25 0:00:00 |
Detection of related substances of apramycin sulphate by HPLC |
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| wuningpeng.Detection of related substances of apramycin sulphate by HPLC[J].Chinese Journal of Veterinary Drug,2009,43(11):33-36. |
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| Authors: | wuningpeng |
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| Institution: | Henan Institute of Veterinary Drug Control |
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| Abstract: | A method for detection of related substances of apramycin sulfate was developed by high performance liquid chromatography. The related substances were sepaereted with a column packed with cation-exchange polymeric beads with sulphonic acid functional groups, derivatizationed by ninhydrin reagent, and detected at 568nm. This method was showed to be suitable to detect the raleted substances of apramycin sulphate. |
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| Keywords: | apramycin sulphate related substances high performance liquid chromatography post-column derivatization |
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