柞蚕全蚕粉对诱导型小鼠糖尿病的预防作用

饲喂添加不同剂量柞蚕全蚕粉的全价配合饲料4周后,通过尾静脉注射四氧嘧啶建立糖尿病小鼠模型,观察柞蚕全蚕粉对糖尿病小鼠血糖、脂代谢甘油三酯(TG),总胆固醇(TC),高密度脂蛋白(HDL-C),低密度脂蛋白(LDL-C)]的影响。结果表明:添食中、高剂量柞蚕全蚕粉可显著降低糖尿病小鼠血糖,分别比阳性对照组降低了31.3%、42.5%(p<0.01)。各剂量组TG、TC、LDL-C较阳性对照组均有不同程度降低,其中:高剂量组LDL-C与阴性对照组无差异(p>0.05);HDL-C较阳性对照组均有升高,中、高剂量组与阳性对照组有显著性差异(p<0.05)。柞蚕全蚕粉能够降低糖尿病小鼠的血糖,且调节糖尿病小鼠的脂代谢和降低TG,TC。

Protective Effects of Tussah Powder on Alloxan-induced Diabetes in Mice

To study the protective effects of Tussah Powder on alloxan-induced diabetes in mice,an experimental diabetes model was established by intravenous injection of alloxan after fed Tussah Powder 4 weeks,the effects of Tussah Powder on diabetes mice were investigated by observing the change of blood glucose,lipometabolic index(TG,TC,HDL-C,LDL-C).Compared to the positive control group,middle and high dose group can decrease the level of blood glucose by 31.3%,42.5%(p<0.01)respectively;the contents of TG,TC,LDL-C of all dose groups decreased differently degree,and the content of LDL-C of high dose group isn't different from negative control group(p>0.05);the contents of HDL-C of all dose group increased,whole middle and high dose group had significantly difference with Model(p<0.05).For alloxan-induced diabetes in mice,Tussah Powder can decrease the level of blood glucose,improve lipometabolic,decrease the fat sediment.Tussah Powder has a significantly protective effect on alloxan-induced diabetes in mice.